Core Research Area

• Cell & Cell-free Therapy

Develop cell therapy and cell free therapy (secretome & extracellular vesicles) for various tissue repair and regeneration. Develop nanovesicle technology driven target delivery of therapeutic molecules for various tissue repair and regeneration. Identification of the molecular markers (micro-RNA and protein coding genes) related to stemness and understanding their role in determining the stem cell fate, their mechanism and signaling pathways contributing to stemness in cervical cancer

• Molecular Signal Transduction

Reversible, non-hormonal male contraceptive development and endeavour for a better understanding of the biochemistry of the gamete functions in mammalian systems, with special emphasis on the interrelation between GSK3 (glycogen synthase kinase 3) and FTO (RNA-specific demethylases) in the regulation of mammalian spermatogenesis and fertility.

Development of gene editing-based approaches to target GSK3, isoform-selectively, to mitigate cancer phenotypes in human acute lymphoblastic leukemia (ALL) cell lines and clinical samples.

For more details, please visit the Lab website: http://deyresearchlab.in

• Biomaterials & 3D bioprinting

We are synthesizing biocompatible hybrid biomaterials that will be suitable for various tissue regeneration and develop scaffolds via 3D bioprinting for drug screening and tissue regeneration.

• Brain Aging & Neurotherapeutics 

Development of anti-aging strategies targeting autophagy pathways against brain aging and age-related neurodegenerative disorders 

Development and validation of a 3D model of brain aging in the dish as an alternative for animal uses for screening  discovery of novel anti-aging  molecules

Development and validation of nano-formulation using a cocktail of caloric restriction mimetics and biopolymeric materials for aging-induced  impaired neurogenesis and cognitive decline 

• Reproductive therapeutics

The research focuses on several key areas within reproductive therapeutics. Firstly, it aims to elucidate the role of stem cells in addressing disorders related to the ovaries and endometrium, with the ultimate goal of developing innovative stem cell-based therapies for reproductive disorders. Additionally, there is an emphasis on the creation of a three-dimensional (3D) disease model for polycystic ovary syndrome (PCOS) and endometriosis, which will facilitate in vitro drug testing and advance our understanding of these complex conditions.  This integrated approach seeks to enhance therapeutic strategies and improve patient outcomes in reproductive health.

• Cancer Immunology and Immunotherapy

Our research lab focuses on advancing cancer immunotherapy through two strategic pillars: (a) the development of gene-edited allogeneic CAR-NK cell therapies and (b) the design of novel bispecific antibodies. By leveraging CRISPR-Cas9, we precisely engineer NK cells to enhance anti-tumor potency and persistence. Central to this effort is the use of non-viral gene delivery systems to optimize safety and manufacturing scalability. Concurrently, we develop bispecific antibodies to dual-target malignant cells and immune checkpoints. Integrating these engineering approached we aim to develop potent, "off-the-shelf" therapeutic solutions which will provide more accessible and effective treatment options across a broad range of oncology indications.

• Bioinformatics and Rare disease screening partners

1.      Suma Genomics Pvt. Ltd.  -  https://sumagenomics.com/

2.      Mbiomics LLC - http://mbiomics.net/index.html